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Dr. Charu Gupta

Assistant Professor

Dr. Charu Gupta is currently working as an Assistant Professor in Clinical Research Division of the School of Basic and Applied Sciences, Galgotias University. Here she is bearing additional responsibilities of the lab coordinator and the research coordinator of the Clinical Research Division. After qualifying, NET and GATE fellowships, she did her PhD work in Institute of Genomics and Integrative Biology (CSIR), Delhi and received her PhD degree from Delhi University. Following her PhD she continued post-doctoral research in various esteemed national and international institutions like National Institute of Immunology, Food and Drug Administration (FDA), USA, Jamia Hamdard, etc. Her keen interest and scientific acumen in molecular parasitology and biomedical research, helped her earn various national and international awards and fellowships like the Oak Ridge Institute for Science and Education (ORISE) Fellowship for research at Centre for Biologics Evaluation and Research, Food and Drug Administration NIH Campus, Bethesda, USA; Fellows Award for Research Excellence (FARE) for research at Centre for Biologics Evaluation and Research, Food and Drug Administration NIH Campus, Bethesda, USA; N-PDF from DST-SERB and DST-WOSA Women Scientist Program. She has presented her research work at several international and national conferences in India and abroad. From the Institute of Molecular Medicine, Jamia Hamdard, New Delhi, she organized a highly successful International Conference on “Innovations for the Elimination and control of Visceral Leishmaniasis in Asia and Africa”. 

Since she has joined university in 2021, she played a key role in the development of research lab for her division. She has completed numerous courses/ FDP/ training/ workshops conducted by highly reputed organizations. She has published 10 research papers in reputed SCI/SCI-E/SCOPUS and peer-reviewed journals along with 3 patents. 

Professional Experience

  • N-PDF from JH-Institute of Molecular Medicine,Jamia Hamdard from 2018-2020
  • Post-doctoral Fellow at Centre for Biologics Evaluation and Research, Food and Drug Administration, NIH Campus, Bethesda, USA from Oct 2010-Sept 2015
  • Principal Scientist at Proteomics and Drug Discovery at ILS Bioservices, Global Discovery Center, IMT Manesar, from July 2009-July 2010
  • Project Associate at National Institute of Immunology, New Delhi, from Oct. 2007- Oct. 2008
  • Junior and Senior Research Fellowat Institute of Genomics and Integrative Biology from Jan 2002-Aug 2007.

Qualification

  • Ph.D. from IGIB, New Delhi, India
  • M. Sc. Biotechnology from Banaras Hindu University

Awards & Recognitions

  • DST-SERB National Post-doctoral Fellowship (N-PDF) for research at Institute of Molecular Medicine, Jamia Hamdard, New Delhi, India (2017)
  • CSIR-UGC NET Junior Research Fellowship at Institute of Genomics and Integrative Biology, Delhi, India (2002-2004)
  • CSIR-UGC NET Senior Research Fellowship at Institute of Genomics and Integrative Biology, Delhi, India (2004-2007)
  • Graduate Aptitude Test in Engineering (GATE) examination conducted by MHRD, Government of India. (2002)

International award

  • Fellows Award for Research Excellence (FARE) for research at Centre for Biologics Evaluation and Research, Food and Drug Administration NIH Campus, Bethesda, USA (2014)
  • The Oak Ridge Institute for Science and Education (ORISE) Fellowship for research at Centre for Biologics Evaluation and Research, Food and Drug Administration NIH Campus, Bethesda, USA

Areas of Specialization

Biomedical Research, Molecular Parasitology, Aptamer development 

Major Publications

  • Novel peptide inhibitor of Human Tumor Necrosis Factor-α has antiarthritic activity. DebasisSahua, Charu Guptaa, Ragothaman Yennamalli, Shikha Sharma, Saugata Roy, Sadaf Hasan, Pawan Gupta, Vishnu Kumar Sharma, Sujit Kashyap, Santosh Kumar, Ved Prakash Dwivedi, Amulya Kumar Panda, Hasi Rani Das, Chuan-Ju Liu. Preprint bioRxiv 2022.12.06.519274; https://doi.org/10.1101/2022.12.06.519274 on 10th December 2022. (a: equal contribution).
  • Aptamer-Based Detection of Disease Biomarkers in Mouse Models for Chagas Drug Discovery. Fernanda Fortes de Araujo, Rana Nagarkatti, Charu Gupta, Ana Paula Marino and Alain Debrabant PLOS Neglected Tropical Diseases 2015, 9 (1): e3451. doi:10.1371/journal.pntd.0003451 ISSN:1935-2735 PMID: 25569299 Impact Factor: 3.83
  • Aptamer based, non-PCR non-serological, detection of chagas disease biomarkers in Trypanosoma cruzi infected mice. Rana Nagarkatti, Fernanda Fortes de Araujo, Charu Gupta and Alain Debrabant. PLOS Neglected Tropical Diseases 2014; 8 (1): e2650. doi:10.1371/journal.pntd.0002650 ISSN:1935-2735 PMID: 24454974 Impact Factor: 3.83
  • Expression of TNF-α and related signaling molecules in the peripheral blood mononuclear cells of rheumatoid arthritis patients. Raghav SK, Gupta B, Agrawal C, Chaturvedi VP and Das HR. Mediat. Inflamma. 2006; 2006(3): 1-5. doi: 10.1155/MI/2006/12682 ISSN: 1466-1861 PMID: 16951485 Impact Factor: 3.23
  • Anti-MBL autoantibodies in patients with rheumatoid arthritis: prevalence and clinical significance. Gupta B, Raghav SK, Agrawal C, Das RH, Chaturvedi VP and Das HR. J. Autoimmunity, 2006; 27 (2), 125-133. 

doi:10.1016/j.jaut.2006.07.002 ISSN: 0896-8411 PMID: 16904869 Impact Factor: 7.64

  • Altered expression and glycosylation of plasma proteins in rheumatoid arthritis. Raghav SK, Gupta B, Agrawal C, Saroha A, Das RH., Chaturvedi VP and Das HR. Glycocon. J. 2006; 23: 169-175. doi: 10.1007/s10719-006-7922-6 ISSN:0282-0080 PMID: 16691500 Impact Factor: 2.18
  • Anti-inflammatory effect of Ruta graveolens L. in murine macrophage cells. Raghav SK, Gupta B, Agrawal C, Goswami K, Das HR. J Ethnopharmacol. 2006; 104(1-2):234-239. doi: 10.1016/j.jep.2005.09.008 ISSN: 0378-8741 PMID: 16207519 Impact Factor: 2.98
  • Association of mannose-binding lectin gene (MBL2) polymorphisms with rheumatoid arthritis in an Indian cohort of case-control samples. Gupta B, Agrawal C, Raghav SK, Das SK, Das RH, Chaturvedi VP, Das HR. J. Hum. Genet. 2005; 50: 583–591. 

doi: 10.1007/s10038-005-0299-8 ISSN:1434-5161 PMID: 16220211 Impact Factor: 2.47

  • Tumor necrosis factor-alpha microsatellite polymorphism association with rheumatoid arthritis in Indian patients. Agrawal C, Raghav SK, Gupta B, Das RH, Chaturvedi VP, Goswami K, Das HR. Arch. Med. Res. 2005; 36 (5):555-9. doi:10.1016/j.arcmed.2005.03.035 ISSN:0188-4409 PMID: 16099338 Impact Factor: 2.72

Patents

  • A disease diagnosis using spectroscopy and machine learning system. Shagun Jain, Dr. Charu Gupta, Lavi Tyagi, Surendra Singh Chauhan, Abhishek Sharma, Shriyansh Srivastava, Dr. Medhavi Malik. Application No. 202211019293, Indian Patent, Publication date- 8/04/2022.
  • Method for the diagnosis of rheumatoid arthritis. Hasi Das, Bhawna Gupta, Sunil Kumar Raghav, Kalyan Goswami, Charu Agrawal and Rakha Hari Das. IPC8 Class: AG01N3353FI, US Patent 7763436, 2010/7/27.
  • Novel diagnostic marker, a diagnostic kit and a method for diagnosis of rheumatoid arthritis. Hasi Das, Bhawna Gupta, Sunil Kumar Raghav, Kalyan Goswami, Charu Agrawal and Rakha Hari Das. US Patent App. 11/281,243, 2006/6/29.

Conference Proceedings/ Conferences

International Conferences

  • “Comparative proteomic analysis of secreted excreted antigens of three strains of Trypanosoma cruzi” OBRR Science Day FDA White Oak, Silver Spring, MD USA 2015 (Charu Gupta, Samuel Mindaye, Vivek Anantharaman, Aravind Iyer, Rana Nagarkatti, and Alain Debrabant; poster presentation).
  • “Comparative proteomic analysis of secreted excreted antigens of three strains of Trypanosoma cruzi” FDA Science Forum, FDA White Oak, Silver Spring, MD USA 2015 (Charu Gupta, Samuel Mindaye, Vivek Anantharaman, Aravind Iyer, Rana Nagarkatti, and Alain Debrabant; poster presentation).
  • “Comparative analysis of secreted excreted antigens of three strains of Trypanosoma cruzi” OBRR Science Day FDA White Oak, Silver Spring, MD USA 2014 (Charu Gupta, Samuel Mindaye, Rana Nagarkatti, and Alain Debrabant; poster presentation).
  • “Non-serological Detection of T. cruzi Biomarkers in Murine Drug Discovery Models of Chagas Disease” American Society of Tropical Medicine and Hygiene Annual Meeting, New Orleans, LA, USA 2014 (Rana Nagarkatti, Fernanda Fortes de Araujo, Charu Gupta, Alain Debrabant; poster presentation) 
  • “Comparative analysis of secreted excreted antigens of three strains of Trypanosoma cruzi” Gordon Research Conference: Biology of Host-Parasite Interactions, Salve Regina University in Newport RI USA, 2014 (Charu Gupta, Samuel Mindaye, Rana Nagarkatti, and Alain Debrabant; poster presentation).
  • “Identification of biomarkers of Trypanosoma cruzi infection in blood using aptamer technology and proteomics” NIH FARE, Bethesda, MD USA 2014 (Charu Gupta, Rana Nagarkatti, Samuel Mindaye, Fernanda Fortes de Araujo, and Alain Debrabant). Received of FARE award 2014.
  • “Identification of biomarkers of Trypanosoma cruzi infection in blood to develop a quantitative sandwich aptamer-based diagnostic test” OBRR Science Day NIH, Bethesda, MD USA 2013 (Gupta C., Nagarkatti R, Mindaye S., de Araujo F.F., and Debrabant A; poster presentation).
  • “Identification of biomarkers of Trypanosoma cruzi infection in blood using aptamers generated against TESA” Kinetoplastid Molecular Cell Biology Meeting Woods Hole, MA USA 2013 (Charu Gupta, Rana Nagarkatti, Samuel Mindaye, Fernanda Fortes de Araujo, and Alain Debrabant; poster presentation).
  • “Evaluation of an aptamer based assay to detect biomarkers of Trypanosoma cruzi infection in mice treated with Benznidazole” Kinetoplastid Molecular Cell Biology Meeting Woods Hole, MA USA 2013 (Fernanda Fortes de Araujo, Rana Nagarkatti, Charu Gupta, Ana Paula Marino and Alain Debrabant; poster presentation).
  • “Detection of Biomarkers of Trypanosoma cruzi Infection in Blood Using an Enzyme-Linked-Aptamer (ELA) Assay” American Society of Tropical Medicine and Hygiene Annual Meeting, Atlanta, GA, USA 2012 (Charu Gupta, Rana Nagarkatti, Fernanda Fortes de Araujo, Alain Debrabant; poster presentation) 
  • “Non-serological detection of parasite biomarkers in human blood for the diagnosis of chagas disease” American Society of Tropical Medicine and Hygiene Annual Meeting, Atlanta, GA, USA 2012 (Rana Nagarkatti, Andrea Teixeira, Silvana Eloi, Olindo Martins-Filho, Fernanda Fortes de Araujo, Charu Gupta, Alain Debrabant; poster presentation) 
  • “Development of a mouse model of chagas disease and an aptamer-based assay to detect biomarkers of Trypanosoma cruzi infection in blood” Gordon Research Conference: Biology of Host-Parasite Interactions, Salve Regina University in Newport RI USA, 2012 (Fernanda Fortes de Araujo, Rana Nagarkatti, Charu Gupta, Ranadhir Dey and Alain Debrabant; poster presentation)
  • “Development of an Aptamer-Based Assay to Detect Biomarkers of Trypanosoma cruzi Infection in a Mouse Model of Chagas Disease” at Annual OBRR Science Fair 2011 (Fernanda Fortes de Araujo, Rana Nagarkatti, Charu Gupta, Ana Paula Marino, Ester Roffe, and Alain Debrabant; poster presentation).
  • “Development of an Aptamer-Based Concentration Method to Improve Detection of Trypanosoma cruzi Parasites in Whole Blood” Annual OBRR Science Fair 2011 (Rana Nagarkatti, Fernanda Fortes de Araujo, Sirena Sun, Vaibhav Bist, Charu Gupta, and Alain Debrabant; poster presentation).
  • “Identification of Serum Biomarkers for Chagas Disease” American Society of Tropical Medicine and Hygiene Annual Meeting, Philadephia, PA, USA 2011 (Rana Nagarkatti, Fernanda de Araujo, Charu Gupta, Alain Debrabant; poster presentation).
  • “Prevalence and clinical significance of anti-MBL autoantibodies in the patients with rheumatoid arthritis” at IBC 10th Drug Discovery Technology and Development World Congress held in Boston, USA, Aug’ 2005. (Gupta B, Raghav SK, Agrawal C and Das HR, poster presentation). 

National Conferences

  • “Anti-inflammatory effect of SR-001 in murine macrophages” at 21st Annual Conference of Indian Rheumatology Association held in Hyderabad, India, Dec’ 2005. (Raghav SK, Gupta B, Agrawal C and Das HR; poster presentation). 
  • “A better serological marker for rheumatoid arthritis” at 21st Annual Conference of Indian Rheumatology Association held in Hyderabad, India, Dec’ 2005. (Gupta B, Raghav SK, Agrawal C and Das HR; oral presentation). 
  • “Tumor necrosis factor- microsatellite polymorphism association with rheumatoid arthritis in Indian population” at 2nd National Conference of the Biotechnology Society of India, BIOTECHCON 2004 held in Delhi, Oct’ 2004. (Agrawal C, Kalyan Goswami, Raghav SK, Gupta B, V. P. Chaturvedi and Das HR; poster presentation). 
  • “Pathological profile of oxidative stress” at 2nd National Conference of the Biotechnology Society of India, BIOTECHCON 2004 held in Delhi, Oct’ 2004. (Kalyan Goswami, Raghav SK, Gupta B, Agrawal C and Das HR; poster presentation). 
  • “Glycosylation alteration and rheumatoid arthritis” at 2nd National Conference of the Biotechnology Society of India, BIOTECHCON 2004 held in Delhi, Oct’ 2004. (Raghav SK, Gupta B, Kalyan Goswami, Agrawal C, V. P. Chaturvedi and Das HR; poster presentation). 
  • “An association study between mannose-binding lectin polymorphism and rheumatoid arthritis in Indian population” at 10th Asian-Pacific Congress of Clinical Biochemistry and 42nd ASC of the AACB held in Perth, Western Australia, Sep’ 2004. (Das HR, Gupta B, Agrawal C, Raghav SK, V. Chaturvedi and R. H. Das; poster presentation). 
  • “TNF-alpha microsatellite polymorphism association in rheumatoid arthritis in Indian population” at 10th FAOBMB Congress held at Indian Institute of Science, Bangalore, India, Dec’ 2003. (Agrawal C, Raghav SK, Gupta B, Ved Chaturvedi and Das HR; poster presentation). 

Certifications

  • Completed a NPTEL certification course (under FDP) on “Computer Aided Drug Design” a 8-week course, conducted from Jul-Sept 2022.
  • Completed a NPTEL certification course (under FDP) on “NBA Accreditation and Teaching and learning in Engineering (NATE)” a 12-week course, conducted from Jan-Apr 2022.
  • Completed a NPTEL certification course (under FDP) on “Interactomics: Basics and Applications” a 12-week course, conducted from Jan-Apr 2022.
  • Completed “TRAC33: Clinical Proteomics and Biomarker Discovery” 35 Lecture/ Lab hours conducted by The Foundation for Advanced Education in the Sciences, Inc. at the National Institutes of Health from June 18-22, 2012. 
  • Completed a course on “Basic Science Writing” conducted by Office of Postdoctoral Services Office of Intramural Training and Education, NIH on May 3, 2011.
  • Completed “Mouse Workshop” conducted by Office of Animal Care and Use, NIH July 15, 2011.